Zum Inhalt springen
Technische Universität München

Welcome to the Spatial Omics Lab

Spatially resolved omics technologies, including spatial transcriptomics and spatial proteomics, have revolutionized the possibilities to study complex pathological processes. At the Institute of Pathology, our Spatial Omics Lab uses state-of-the-art spatial transcriptomics (Xenium In Situ) and spatial proteomics (CODEX) technologies to investigate different aspects of cancer, aiming to find better treatment options for patients. Further, we are dedicated to building open-source computational frameworks to improve the integration of pathological expert knowledge into computational analyses and simplify the analysis of complex datasets.

Research area

Our current research projects include the following topics:

  • Intra-Tumoral Heterogeneity and tumor microenvironment in Pancreatic ductal adenocarcinoma
  • Role of the vascular system in different cancer entities, including glioblastoma and breast cancer
  • Impact of radiation therapy on vascular system in glioblastoma patients
  • Development of computational frameworks for a histology-guided analysis of multi-sample datasets

To make cutting-edge technologies like Xenium In Situ accessible to more researchers, we offer to use the platform within the framework of scientific collaborations. If you are interested to use the technology in your research project, please contact us using the contact information below.

Affiliations

Our lab is affiliated with:

Further, our lab is part of the following research consortia:

  • SATURN3: Spatial and temporal resolution of intratumoural heterogeneity in the three difficult-to-treat cancers breast cancer, colorectal cancer and pancreatic cancer.
  • UbiQancer (TRR 387): Functionalization of the ubiquitin system against cancer.
Applications

If you are interested in doing a bachelor thesis, master thesis or internship in our lab, feel free to apply using the contact information below.

Team
  • Dr. rer. nat. Johannes Wirth – Lab head Spatial Transcriptomics
  • Dr. rer. nat. Courtney König – Lab head Spatial Proteomics
  • Dr. med. vet. Katja Steiger – Supervisor and head of CEP and tissue bank at TUM
  • Nadja Lewandowski-Hoppe – Technician
  • Anna Chernysheva, M.Sc. – Bioinformatician
  • Xinxuan He, M.Sc. – Biologist
  • Birthe Lemke, B.Sc. – Master student
  • Sarah Ouologuem, B.Sc. – Master student
  • Mariam Zaidi, B.Sc. – Master student
  • Dr. med. vet. Eva Daldrup – Medical doctoral student
  • Martin Betcher – Medical doctoral student

Former members

  • Aitana Egea Lavandera – Intern
  • Marina Momina – Bachelor student
  • Isabel Giray – Research assistant
Contact

E-mail: j.wirth(at)tum.de

To top