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Welcome to TUM Institute of Neuronal Cell Biology

The Institute of Neuronal Cell Biology belongs to the TUM School of Medicine and Health and is located at the Center for Neuroscience at Campus Biederstein of the Technische Universität München.

General Introduction

The Institute of Neuronal Cell Biology (headed by Prof. Thomas Misgeld and Prof. Mikael Simons) studies questions related to how neurons and the surrounding glial cells interact in development and disease (for example multiple sclerosis, neurodegenerative disorders or trauma). Our sister institute at Biederstein Campus is the Institute of Neuroscience. We are also affiliated with the German Center for Neurodegenerative Diseases (DZNE) and co-cordinate the DFG Excellence Cluster SyNergy. 

Our work is focused on three areas:

  1. The mechanisms by which axons are remodeled and dismantled;
  2. How the axon-myelin unit forms, and how it responds to disease-related damage;
  3. How neurogenesis and neuronal differentiation contribute to the formation of specific well characterized circuits (e.g. in the retina or the neuromuscular system).

The Institute comprises the following research groups:

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Headlines

May 2025

  • The Excellence Cluster SyNergy was successful in the third funding period 2026-2032!! Thomas Misgeld is co-speaker of the Cluster together with LMU colleagues Magdalena Götz and Martin Dichgans.

June 2024

  • Natalia Marahori successfully defended her PhD thesis on the 10th of June. Congratulations Natalia!

January 2024

  • The transregional collaborative research center TRR 274 “Checkpoints of central nervous system recovery” was funded by the DFG for a second period (2024-2027). Thomas Misgeld (in collaboration with Christine Stadelmann and Martin Kerschensteiner) and Leanne Godinho (in collaboration with Ruben Portugues) are grant recipients.

December 2023

  • Shahrzad Askari and Thomas Misgeld wrote a News and Views commentary "Brain imaging turned inside out" about a study published in Nature Biotechnology.

September 2023

  • Antoneta Gavoci successfully defended her PhD thesis on the 14th of September. Congratulations Antoneta!

August 2023

  • Congratulations Yi-Heng Tai on your work being published in Nature Metabolism! In a joint effort between the Kerschensteiner lab (LMU) and the Misgeld lab, the molecular composition and functional capacity of neuronal mitochondria was investigated in response to inflammation. This led to the identification of the TCA cycle as a new potential target for therapeutic interventions in multiple sclerosis. Read a News and Views piece about this work. Read the press release from Synergy.

June 2023

  • Our Nature Protocols paper "Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice" has just been published.

April 2023

  • Joint work from the Kerschensteiner lab (LMU) and the Misgeld lab is out in Neuron. In this paper, whether and how mature oligodendrocytes that survive in  lesions in multiple sclerosis (MS) patients and animal models of MS contribute to myelin repair was investigated. 

February 2023

  • Eleni Petridou successfully defended her PhD thesis on the 10th of February 2023!! 

 

 

Archived News

 

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