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Welcome to TUM Institute of Neuronal Cell Biology

The Institute of Neuronal Cell Biology belongs to the TUM School of Medicine and Health and is located at the Center for Neuroscience at Campus Biederstein of the Technische Universität München.

General Introduction

The Institute of Neuronal Cell Biology (headed by Prof. Thomas Misgeld and Prof. Mikael Simons) studies questions related to how neurons and the surrounding glial cells interact in development and disease (for example multiple sclerosis, neurodegenerative disorders or trauma). Our sister institute at Biederstein Campus is the Institute of Neuroscience. We are also affiliated with the German Center for Neurodegenerative Diseases and co-cordinate the DFG Excellence Cluster SyNergy. For other collaborating institutes at TUM, please visit here.

Our work is focused on three areas:

  1. The mechanisms by which axons are remodeled and dismantled;
  2. How the axon-myelin unit forms, and how it responds to disease-related damage;
  3. How neurogenesis and neuronal differentiation contribute to the formation of specific well characterized circuits (e.g. in the retina or the neuromuscular system).

The Institute comprises the following research groups:

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Headlines

June 2024

  • Natalia Marahori successfully defended her PhD thesis on the 10th of June. Congratulations Natalia!

January 2024

  • The transregional collaborative research center TRR 274 “Checkpoints of central nervous system recovery” was funded by the DFG for a second period (2024-2027). Thomas Misgeld (in collaboration with Christine Stadelmann and Martin Kerschensteiner) and Leanne Godinho (in collaboration with Ruben Portugues) are grant recipients.

December 2023

  • Shahrzad Askari and Thomas Misgeld wrote a News and Views commentary "Brain imaging turned inside out" about a study published in Nature Biotechnology.

September 2023

  • Antoneta Gavoci successfully defended her PhD thesis on the 14th of September. Congratulations Antoneta!

August 2023

  • Congratulations Yi-Heng Tai on your work being published in Nature Metabolism! In a joint effort between the Kerschensteiner lab (LMU) and the Misgeld lab, the molecular composition and functional capacity of neuronal mitochondria was investigated in response to inflammation. This led to the identification of the TCA cycle as a new potential target for therapeutic interventions in multiple sclerosis. Read a News and Views piece about this work. Read the press release from Synergy.

June 2023

  • Our Nature Protocols paper "Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice" has just been published.

April 2023

  • Joint work from the Kerschensteiner lab (LMU) and the Misgeld lab is out in Neuron. In this paper, whether and how mature oligodendrocytes that survive in  lesions in multiple sclerosis (MS) patients and animal models of MS contribute to myelin repair was investigated. 

February 2023

  • Eleni Petridou successfully defended her PhD thesis on the 10th of February 2023!! 

March 2022

  • Congratulations Yan Xiao (Czopka lab) !!  In a collaboration with Ruben Portugues and Luigi Petrucco, TUM Institute for Neuroscience, Xiao et al. report a new role for OPCs in regulating axonal remodeling in the visual system of zebrafish (Nature Neuroscience).

February 2022

  • Congratulations Marina Herwerth and Selin Kenet (Misgeld Lab)!!  Co-first authors on a paper reporting a distinct form of immune-mediated axon pathology in NMO in the journal Brain.
  • Congratulations Stavros Vagionitis and Franzi Auer (Czopka Lab) - joint co-first authors on a paper in Cell Reports, which reveals the role of neurofascin in the positioning of nodes of Ranvier along axons.

December 2021

  • Monika Leischner-Brill successfully completed her Habilitation at the TUM, Faculty of Medicine. Congratulations Moni!
  • Selin Kenet (Misgeld lab) successfully defended her PhD thesis on Dec 2nd. Well done Selin!

November 2021

  • Peter Engerer's and Eleni Petridou's paper on the role of Notch in cell fate plasticity was highlighted in the current issue of Current Biology!. Read the article.
  • On Nov 10th, Roberta Marisca from the Czopka lab successfully defended her thesis "Investigating mechanisms of axon-oligodendrocyte precursor cell communication in vivo". Well done Roberta!

October 2021

  • Monika Leischner-Brill along with Magda Magiera (Institut Curie) organized Microtubules in Neurons 2021, a focused conference at the Fraueninsel on Lake Chiemsee from Oct 24-27. The event was supported by the Deutsch-Französische Hochschule.
  • Stavros Vagionitis from the Czopka lab successfully defended his thesis "Studying axonal and glial dynamics during CNS myelination and remyelination in vivo using zebrafish" on October 7th. Congratulations Stavros!

September 2021

  • Peter Engerer's and Eleni Petridou's joint paper on the role of Notch in cell fate plasticity in the retina is out in Current Biology!.

February 2021

  • Mengzhe (Grace) Wang's and Monika Leischner-Brill's paper on local co-ordination between axon remodeling and myelination is out in the Journal of Cell Biology. This paper was highlighted for JCB's special collection of Cellular Neurobiology. Read more here. Congratulations!
  • Caro Fecher's and Laura Trovo's (Misgeld lab) Nat Neurosci paper on cell-type-specific profiling of brain mitochondria was highligted in the Focus issue on Neuroscience Methods of Nature Neuroscience.

January 2021

  • Monika Leischner-Brill has been awarded a DFG grant to investigate the role of microtubule modification and severing in axon remodeling during synapse elimination at the neuromuscular junction. Congratulations Moni!
  • In work just published in Nature Neuroscience Nic Snaidero (Misgeld lab) together with co-first authors Mehrnoosh Jafari and Minh Schumacher (Kerschensteiner lab) reported about the role of immune-mediated synapse loss in a multiple sclerosis model. This was a joint effort by the labs of Martin Kerschensteiner, Thomas Misgeld and Doron Merkler.  Read more about this work here.

September 2020

  • Nic Snaidero's paper on myelin replacement in the mouse cortex is out in Nature Communications  and featured in the Editor's highlights ! This was a collaboration between the labs of Thomas Misgeld and Martin Kerschensteiner.

February 2020

  • New paper out in Nature Neuroscience from the Czopka lab! Joint co-first authors Roberta Marisca and Tobias Hoche report on functionally distinct types of oligodendrocyte precursor cells. Read here.

 

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